Our laboratory studies the organisation of the cell nucleus,
using fluorescently-tagged proteins and antibodies to "map"
specific regions and structures. We are also purifying many of these
structures in order to identify as many of their protein components
as possible via proteomic approaches,
which will give us important clues to the functions of these structures
within the cell.
Many complicated cellular functions are carried out in the nucleus,
and the substructures shown below are known in some cases to be
sites where these functions actually occur, and in other cases to
be "storage depots" for particular proteins required by
these processes. By keeping the proteins in particular regions of
the nucleus, they can be recruited quickly as needed.
For more information about the use of fluorescent protein tags to
study protein localization, click here.
For more information about the use of electron microscopy to study
protein localization, click here.
For more information about our proteomic studies, click here.